Candidate Cell Substrates, Vaccine Production, and Transmissible Spongiform Encephalopathies
نویسندگان
چکیده
منابع مشابه
Candidate Cell Substrates, Vaccine Production, and Transmissible Spongiform Encephalopathies
Transmissible spongiform encephalopathy (TSE) agents have contaminated human tissue-derived medical products, human blood components, and animal vaccines. The objective of this study was to determine the potential susceptibility to infection of 5 cell lines used or proposed for manufacture of biological products, as well as other lines. Cell lines were exposed to the infectious agents of sporad...
متن کاملTransmissible Spongiform Encephalopathies
Neuronal death represents the primary pathology of neurodegenerative diseases such as Alzheimer's and Parkinson’s disease and Amyotrophic Lateral Sclerosis. These diseases usually present with a slow onset and a chronic progression. Various regions of the brain, spinal cord, or peripheral nerves may be affected, leading to functional impairment and neuron loss. Neurodegenerative diseases are of...
متن کاملHuman Transmissible Spongiform Encephalopathies
Creutzfeldt-Jakob disease (CJD) is a rare and fatal human neurodegenerative condition characterized in most cases by a rapidly progressive dementia, myoclonus, and a periodic electroencephalogram (EEG). It is classified as a transmissible spongiform encephalopathy (TSE) because it causes characteristic spongy degeneration of the brain and can be transmitted to laboratory animals. TSEs also affe...
متن کاملTransmissible spongiform encephalopathies
Keywords Disease name and synonyms Included diseases Definition Pathogenesis Sporadic CJD Genetic forms of TSE Acquired forms of TSE Treatment Conclusion References Abstract Human prion diseases or transmissible spongiform encephalopathies (TSE) are rare transmissible diseases affecting the central nervous system. The infectious agents are composed of an abnormal isoform of a host membrane prot...
متن کاملTransmissible spongiform encephalopathies.
Vet Med Today: Zoonosis Update 1705 T spongiform encephalopathies affect humans and other animals. Clinically, the diseases involve severe, progressive neurodegeneration with an invariably fatal outcome. The TSEs are linked by the unusual nature of their causative agent, which is believed to be a transmissible protein devoid of nucleic acid. This protein, known as a prion (a pseudoabbreviation ...
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ژورنال
عنوان ژورنال: Emerging Infectious Diseases
سال: 2011
ISSN: 1080-6040,1080-6059
DOI: 10.3201/eid1712.110607